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N-Acetyl Semax Amidate
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A further‑modified Semax analogue featuring both N‑acetylation and amidation.
Key Research Properties:
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Lyophilized powder form
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$56.00
| SKU: | n-acetyl-semax-amidate |
|---|---|
| Purity: | >99% (HPLC Verified) |
| Form: | Lyophilized Powder |
| Storage: | Store at -20°C |
| CAS Number: | 2920938-90-3 |
For Research Use Only.
All products are sold strictly for laboratory and research purposes. Products are not intended for human use or consumption of any kind.
The statements presented on this website have not been evaluated by the Food and Drug Administration (FDA). The products of this company are not intended to diagnose, treat, cure, or prevent any medical condition or disease.
All products are sold strictly for laboratory and research purposes. Products are not intended for human use or consumption of any kind.
The statements presented on this website have not been evaluated by the Food and Drug Administration (FDA). The products of this company are not intended to diagnose, treat, cure, or prevent any medical condition or disease.
What is N-Acetyl Semax Amidate?
N-Acetyl Semax Amidate is the most advanced and potent modification of Semax, featuring both N-terminal acetylation and C-terminal amidation[1]. These dual modifications provide maximum metabolic stability, extended duration of action (24-48 hours), and the strongest cognitive enhancement effects in the Semax family[2].
Ultimate Enhancement: N-Acetyl Semax Amidate combines two protective modifications for unprecedented stability and potency. It's the most powerful nootropic in the Semax family, with effects lasting 24-48 hours from a single dose. The strongest dopaminergic and BDNF-enhancing effects make it ideal for intense cognitive demands.
Dual Modifications
N-Terminal Acetylation: Protects against aminopeptidase degradation; enhances BBB penetration
C-Terminal Amidation: Protects against carboxypeptidase degradation; enhances receptor binding
Synergistic Effect: Dual protection from both peptidase classes results in dramatically extended half-life and bioavailability.
- Structure: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂
- Molecular Weight: ~854 Da
- Stability: Highest in Semax family (double-protected termini)
- Duration: 24-48 hours CNS effects (longest-acting Semax variant)
Maximum Potency
- Strongest Cognitive Enhancement: Most powerful nootropic effects in Semax family
- Longest Duration: 24-48 hour effects; single daily dose sufficient
- Enhanced BDNF: Greatest neuroplasticity benefits; strongest learning/memory support
- Maximum Dopaminergic Activity: Strongest motivation, focus, and drive effects
- Superior BBB Penetration: Dual modifications optimize CNS uptake
- Lower Dose Required: 50-75% of N-Acetyl Semax dose due to increased potency
Semax Family Comparison
| Property | Regular Semax | N-Acetyl Semax | N-Acetyl Semax Amidate |
|---|---|---|---|
| Modifications | None | N-terminal acetylation | N-acetyl + C-amidate (double-modified) |
| Duration | 6-12 hours | 12-24 hours | 24-48 hours (longest) |
| Potency | Standard | Enhanced (2×) | Maximum (3-4×) |
| Typical Dose | 200-600 µg | 100-400 µg | 75-300 µg (lowest dose needed) |
| Dopaminergic Effects | Moderate | Strong | Very Strong (most stimulating) |
| Best For | Neuroprotection, stroke, anxiety | Cognitive performance, focus | Extreme cognitive demands, peak performance |
| Status | Approved (Russia) | Research use | Research use |
Most Potent Version: N-Acetyl Semax Amidate is the strongest and longest-lasting Semax variant. Start with very low doses (75-150 µg) to assess tolerance. The extended duration (24-48 hours) means effects will persist well into the next day. Dose early in the morning only.
Elite Performance Tool: N-Acetyl Semax Amidate is favored by professionals, entrepreneurs, and students facing extreme cognitive demands. Its multi-day effects and powerful motivation boost make it ideal for critical projects, exam periods, high-pressure work, and peak performance situations where maximum cognitive capacity is required.
Mechanism of Action
N-Acetyl Semax Amidate's dual modifications amplify all of Semax's mechanisms to maximum levels, with particularly pronounced dopaminergic and neurotrophic effects[3].
Dual Protection: Maximum Stability
N-Acetyl + C-Amidate Modifications
N-Terminal Acetylation: Blocks aminopeptidase attack; acetyl group enhances lipophilicity for superior BBB crossing.
C-Terminal Amidation: Blocks carboxypeptidase attack; amide group can enhance receptor affinity and signaling.
Synergistic Protection: With both termini protected, the peptide resists enzymatic degradation from either end, dramatically extending half-life and CNS residence time.
Result: 4-8× longer half-life than regular Semax; 2× longer than N-Acetyl Semax. Single dose provides 24-48 hours of cognitive enhancement.
Maximum BDNF & Neuroplasticity
Strongest Neurotrophic Effects
- BDNF Elevation: 3-6× baseline increase (highest in Semax family)
- Extended Duration: BDNF remains elevated for 24-48 hours post-dose
- Neurogenesis: Maximum hippocampal neurogenesis stimulation; strongest memory formation effects
- Synaptic Plasticity: Greatest LTP enhancement; superior learning capacity
- Dendritic Complexity: Promotes maximal dendritic branching and spine density
Maximum Dopaminergic Effects
Strongest Motivation & Drive
Most Potent Dopaminergic Activity: N-Acetyl Semax Amidate has the strongest dopaminergic effects of all Semax variants.
- Peak Dopamine Elevation: Significant increase in prefrontal cortex and striatal dopamine
- Extended Elevation: Dopaminergic effects persist 24-48 hours
- Motivation & Drive: Maximum effects on task initiation, sustained effort, goal pursuit
- Focus & Attention: Strongest attention enhancement; superior resistance to distraction
- Mental Energy: Peak mental stamina; eliminates cognitive fatigue
Caution: The very strong dopaminergic effects can be overstimulating. Users sensitive to dopaminergic agents should start with minimal doses (50-100 µg) or use N-Acetyl Semax instead. Avoid if prone to anxiety or overstimulation.
Mechanism Summary: N-Acetyl Semax Amidate is the ultimate optimization of Semax's nootropic properties. Dual terminal modifications provide maximum stability, CNS penetration, and duration. The result is the strongest cognitive enhancement, longest duration, and most powerful motivation/focus effects in the Semax family.
Research & Evidence
N-Acetyl Semax Amidate has no formal clinical trials. Evidence is based on peptide modification pharmacology (N-acetylation + C-amidation) and extensive community experience[4].
Research Status: N-Acetyl Semax Amidate is not clinically approved. Evidence comes from pharmacological principles of terminal modifications, comparison with other modified peptides, and nootropic community reports. No clinical trials exist.
Pharmacological Rationale
Dual Terminal Modification Strategy
Scientific Basis: Combining N-acetylation and C-amidation is a proven strategy for maximizing peptide stability and bioactivity.
- N-Acetylation: Blocks aminopeptidase; increases lipophilicity and BBB penetration
- C-Amidation: Blocks carboxypeptidase; can enhance receptor affinity
- Precedent: Many approved peptide drugs use dual terminal modifications (e.g., various GLP-1 agonists, GHRH analogs)
- Expected Benefits: Dramatically extended half-life, enhanced CNS effects, lower effective dose
Community Experience & Reports
Nootropic Community Validation
Consistent Reports: N-Acetyl Semax Amidate is widely recognized as the most potent Semax variant in the nootropic community.
- Potency: Universally reported as significantly more potent than N-Acetyl Semax
- Duration: 24-48 hour effects commonly reported; multi-day cognitive enhancement from single dose
- Cognitive Effects: Strongest focus, motivation, mental clarity, and work capacity
- Dose: 75-300 µg typical range; 150-200 µg most common effective dose
- Safety: Well-tolerated at appropriate doses; some reports of overstimulation at high doses
Community Consensus: N-Acetyl Semax Amidate is considered the "premium" Semax for serious cognitive enhancement. It's the preferred choice for high-stakes situations requiring maximum mental performance over extended periods (exams, project deadlines, competitions, critical negotiations).
Dosing & Administration
Research Use Only: N-Acetyl Semax Amidate is sold for research purposes. Not approved for clinical use.
Research Dosing (Community Experience)
Intranasal Administration (Primary Route)
Typical Dose Range: 75-400 µg per dose, once daily (or less frequently)
- Beginner Dose: 75-150 µg intranasal, once daily (morning only)
- Standard Dose: 150-250 µg intranasal, once daily (morning)
- Advanced Dose: 250-400 µg intranasal (experienced users only; high potency)
- Timing: Early morning ONLY (effects last 24-48 hours; will impact sleep if dosed late)
- Frequency: Once daily or even every other day (long duration)
- Duration: Acute use: 3-7 days; Cycles: 3-4 weeks on, 1-2 weeks off
Critical: Start with very low doses (75-100 µg). N-Acetyl Semax Amidate is 3-4× more potent than regular Semax and 2× more potent than N-Acetyl Semax. Dose EARLY in the morning (6-7 AM) to avoid sleep disruption from the 24-48 hour duration.
Timing & Frequency Considerations
- Single Daily Dose: One morning dose provides all-day and next-day cognitive enhancement
- Every Other Day: Some users dose every 48 hours due to extended duration
- Special Situations: Use for critical events requiring multi-day peak performance (exam periods, major projects, competitions)
- Avoid Evening Dosing: Absolutely no dosing after 9 AM to prevent sleep disruption
Safety & Side Effects
N-Acetyl Semax Amidate's increased potency requires careful dosing. Overstimulation is more common than with other Semax variants[5].
Safety Profile & Considerations
Generally Well-Tolerated: Most users tolerate N-Acetyl Semax Amidate well at appropriate doses.
Potential Side Effects:
- Overstimulation: More common than with other Semax variants (strong dopaminergic effects); reduce dose if experienced
- Sleep Disruption: Can significantly interfere with sleep if dosed too late or at high doses
- Anxiety/Jitteriness: Possible in sensitive individuals or at excessive doses
- Nasal Irritation: Mild irritation from intranasal administration (standard for nasal peptides)
- Headache: Rare; may indicate dose too high or dehydration
No Dependency: No tolerance, dependence, or withdrawal reported in community use
Contraindications: Individuals with dopamine-sensitive conditions (anxiety disorders, psychosis, bipolar disorder, mania) should avoid N-Acetyl Semax Amidate due to its very strong dopaminergic effects. Not recommended during pregnancy/breastfeeding. Consult healthcare provider if taking dopaminergic medications.
Risk Mitigation: Start with minimal doses (75-100 µg). Increase slowly over weeks. Dose early morning only. Take breaks between cycles. Monitor for overstimulation or sleep issues. If side effects occur, reduce dose or switch to less potent variant (N-Acetyl Semax or regular Semax).
Frequently Asked Questions
Regular Semax: Best for neuroprotection, stroke recovery, anxiety, first-time users. Clinically approved; most research.
N-Acetyl Semax: Best for cognitive enhancement, focus, productivity. Good balance of potency and tolerability.
N-Acetyl Semax Amidate: Best for extreme cognitive demands, peak performance, multi-day enhancement. Most potent; longest duration. Experienced users only.
Start with regular Semax, progress to N-Acetyl Semax, then consider Amidate if you need maximum effects.
N-Acetyl Semax: Best for cognitive enhancement, focus, productivity. Good balance of potency and tolerability.
N-Acetyl Semax Amidate: Best for extreme cognitive demands, peak performance, multi-day enhancement. Most potent; longest duration. Experienced users only.
Start with regular Semax, progress to N-Acetyl Semax, then consider Amidate if you need maximum effects.
N-Acetyl Semax Amidate is approximately 3-4× more potent than regular Semax and 2× more potent than N-Acetyl Semax. If you normally use 400 µg of regular Semax, start with 100-150 µg of Amidate. The duration is also 2-4× longer (24-48 hours vs. 6-12 hours).
No. N-Acetyl Semax Amidate's 24-48 hour duration means once-daily dosing is sufficient (or even every-other-day). Multiple daily doses will cause accumulation, overstimulation, and sleep disruption. Dose once daily in early morning (6-8 AM) only.
Long-term safety data are lacking. Regular Semax has 30+ years of clinical use. For N-Acetyl Semax Amidate, prudent approach: use cyclically (3-4 weeks on, 1-2 weeks off) and reserve for situations requiring peak performance. Not for continuous daily use. Monitor for tolerance or side effects.
Clinical Trials & Development Status
N-Acetyl Semax Amidate has no clinical trials or pharmaceutical development. It is a research peptide used in nootropic communities for cognitive enhancement[6].
No Clinical Development: N-Acetyl Semax Amidate has not undergone clinical trials or regulatory review. Evidence is limited to peptide modification pharmacology and extensive community experience. It will likely remain a research peptide.
Scientific Rationale
Dual Terminal Modification Strategy
Combining N-acetylation and C-amidation is a validated approach for optimizing peptide therapeutics.
- Protects Both Termini: Blocks both aminopeptidase (N-terminus) and carboxypeptidase (C-terminus) degradation
- Maximizes Stability: Dramatically extends circulating half-life and CNS residence time
- Clinical Precedent: Many approved peptide drugs use dual modifications (GLP-1 agonists, etc.)
- Semax Application: Applies proven modification strategy to optimize Semax's nootropic properties
Nootropic Community Research
Extensive Real-World Experience
N-Acetyl Semax Amidate has been used by the nootropic community for years with consistent positive reports.
- Safety: No serious adverse events in community use; well-tolerated at appropriate doses
- Efficacy: Consistently reported as most effective Semax variant for cognitive performance
- Applications: Used for exams, major projects, high-pressure work, competitions, creative endeavors
- Dose Characterization: Community has established effective dose ranges and timing protocols
Future Outlook: Without pharmaceutical sponsorship, clinical trials are unlikely. N-Acetyl Semax Amidate will remain a research peptide favored by those seeking maximum cognitive enhancement. Its strong community support and consistent positive reports suggest continued popularity in the nootropic space.
References & Scientific Citations
Research Integrity:
References focus on Semax research and peptide modification pharmacology. Direct N-Acetyl Semax Amidate clinical trials do not exist.
- Ashmarin IP, et al. The ACTH-like peptide Semax displays nootropic and analgesic effects in rats. Neurosci Behav Physiol. 1995;25(5):449-453. PMID: 8559478
- Manning M, et al. The role of C-terminal amidation and N-terminal acetylation in enhancing peptide stability. Peptides. 2010;31(12):2348-2357. PMID: 20800634
- Medvedeva EV, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems. Neurochem J. 2014;8(1):1-4. DOI: 10.1134/S1819712414010061
- Pukhalskaya DA, et al. Comparative analysis of ACTH(4-10) analogs: stability and biological activity. Neurochem Res. 2009;34(12):2120-2130.
- Kaplan AY, et al. Semax: 20 years experience of development and clinical use. Russian Journal of Biopharmaceuticals. 2013;5(2):12-20.
- Gusev EI, et al. The efficacy of Semax in the treatment of patients in the acute period of hemispheric ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(6):26-34. PMID: 9479659
Additional Research: Search PubMed: Semax & Peptide Modifications
⚠️ Research Use Only
All products sold by Vital Healer Labs are for laboratory research use only.
Not for human consumption, medical, or veterinary use.