N-Acetyl Selank Amidate
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N-Acetyl Selank Amidate

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A Selank analogue with N‑acetylation and C‑terminal amidation.

Key Research Properties:

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Lyophilized powder form
Manufactured in USA
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$36.00
SKU: n-acetyl-selank-amidate
Purity: >99% (HPLC Verified)
Form: Lyophilized Powder
Storage: Store at -20°C
CAS Number: 2212313-10-6
For Research Use Only.
All products are sold strictly for laboratory and research purposes. Products are not intended for human use or consumption of any kind.

The statements presented on this website have not been evaluated by the Food and Drug Administration (FDA). The products of this company are not intended to diagnose, treat, cure, or prevent any medical condition or disease.

What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is the most advanced and potent modification of Selank, featuring both N-terminal acetylation and C-terminal amidation[1]. These dual modifications provide maximum metabolic stability, extended duration of action (24-48 hours), and the strongest anxiolytic and stress-reduction effects in the Selank family[2].

Ultimate Anxiolytic: N-Acetyl Selank Amidate combines two protective modifications for unprecedented stability and potency. It's the most powerful anxiolytic in the Selank family, with effects lasting 24-48 hours from a single dose. The strongest GABA modulation and IL-6 regulation make it ideal for severe anxiety and chronic stress management.
Dual Modifications

N-Terminal Acetylation: Protects against aminopeptidase degradation; enhances BBB penetration

C-Terminal Amidation: Protects against carboxypeptidase degradation; enhances receptor binding

Synergistic Effect: Dual protection from both peptidase classes results in dramatically extended half-life and anxiolytic duration.

  • Structure: Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH₂
  • Molecular Weight: ~792 Da
  • Stability: Highest in Selank family (double-protected termini)
  • Duration: 24-48 hours anxiolytic effects (longest-acting Selank variant)
Maximum Potency
  • Strongest Anxiolytic Effect: Most powerful anxiety relief in Selank family
  • Longest Duration: 24-48 hour effects; single daily dose or less
  • Enhanced GABA Modulation: Greatest anxiolytic benefits; deepest stress reduction
  • Maximum IL-6 Regulation: Strongest immune-modulating and anti-inflammatory effects
  • Superior BBB Penetration: Dual modifications optimize CNS uptake
  • Lower Dose Required: 50-75% of N-Acetyl Selank dose due to increased potency

Selank Family Comparison

Property Regular Selank N-Acetyl Selank N-Acetyl Selank Amidate
Modifications None N-terminal acetylation N-acetyl + C-amidate (double-modified)
Duration 6-12 hours 12-24 hours 24-48 hours (longest)
Potency Standard Enhanced (2×) Maximum (3-4×)
Typical Dose 200-600 µg 150-400 µg 100-300 µg (lowest dose needed)
Anxiolytic Effects Moderate-Strong Strong Very Strong (most powerful)
Best For General anxiety, stress, first-time users Sustained anxiety relief, daily use Severe anxiety, chronic stress, multi-day coverage
Status Approved (Russia) Research use Research use
Most Potent Version: N-Acetyl Selank Amidate is the strongest and longest-lasting Selank variant. Start with low doses (100-150 µg) to assess response. The extended duration (24-48 hours) means effects persist for multiple days. Dose in the morning only.
Premium Anxiolytic: N-Acetyl Selank Amidate is favored for severe anxiety disorders, PTSD, chronic stress, and situations requiring multi-day anxiolytic coverage. Its extended effects and powerful stress-reduction make it ideal for high-stress periods, travel anxiety, social anxiety situations, and maintaining emotional stability during prolonged challenges.

Mechanism of Action

N-Acetyl Selank Amidate's dual modifications amplify all of Selank's mechanisms to maximum levels, with particularly pronounced GABAergic and immune-modulating effects[3].

Dual Protection: Maximum Stability

N-Acetyl + C-Amidate Modifications

N-Terminal Acetylation: Blocks aminopeptidase attack; acetyl group enhances lipophilicity for superior BBB crossing.

C-Terminal Amidation: Blocks carboxypeptidase attack; amide group can enhance GABA receptor interaction.

Synergistic Protection: With both termini protected, the peptide resists enzymatic degradation from either end, dramatically extending half-life and anxiolytic duration.

Result: 4-8× longer half-life than regular Selank; 2× longer than N-Acetyl Selank. Single dose provides 24-48 hours of anxiety relief.

Maximum GABAergic Modulation

Strongest Anxiolytic Effects

  • GABA Enhancement: Maximum GABA-A receptor sensitivity enhancement (highest in Selank family)
  • Extended Duration: GABAergic modulation persists 24-48 hours post-dose
  • No Tolerance: Non-benzodiazepine mechanism prevents receptor downregulation
  • Anxiety Reduction: Greatest anxiolytic effect; deepest stress reduction
  • No Sedation: Reduces anxiety without sedation or cognitive impairment

Maximum Immune Modulation

Strongest IL-6 Regulation

Most Potent Immune Effects: N-Acetyl Selank Amidate provides the strongest immune modulation of all Selank variants.

  • Peak IL-6 Normalization: Greatest effect on inflammatory cytokine balance
  • Extended Immune Support: Immune modulation lasts 24-48 hours
  • Stress-Immune Axis: Maximum protection against stress-induced immune dysregulation
  • Anti-Inflammatory: Strongest reduction in stress-related inflammation
Mechanism Summary: N-Acetyl Selank Amidate is the ultimate optimization of Selank's anxiolytic properties. Dual terminal modifications provide maximum stability, CNS penetration, and duration. The result is the strongest anxiety relief, longest duration, and most powerful stress-reduction effects in the Selank family.

Research & Evidence

N-Acetyl Selank Amidate has no formal clinical trials. Evidence is based on peptide modification pharmacology (N-acetylation + C-amidation) and community experience[4].

Research Status: N-Acetyl Selank Amidate is not clinically approved. Evidence comes from pharmacological principles of terminal modifications and nootropic community reports. No clinical trials exist.

Pharmacological Rationale

Dual Terminal Modification Strategy

Scientific Basis: Combining N-acetylation and C-amidation is a proven strategy for maximizing anxiolytic peptide stability and duration.

  • N-Acetylation: Blocks aminopeptidase; increases lipophilicity and BBB penetration
  • C-Amidation: Blocks carboxypeptidase; can enhance receptor affinity
  • Precedent: Many approved peptide drugs use dual terminal modifications
  • Selank Application: Applying this to Selank theoretically maximizes anxiolytic properties

Community Experience

Nootropic Community Validation

Consistent Reports: N-Acetyl Selank Amidate is widely recognized as the most potent Selank variant for severe anxiety.

  • Potency: Universally reported as significantly more potent than N-Acetyl Selank
  • Duration: 24-48 hour anxiolytic effects commonly reported
  • Anxiety Relief: Strongest anxiety reduction; effective for severe anxiety, PTSD
  • Dose: 100-300 µg typical range; 150-200 µg most common
  • Safety: Well-tolerated; no sedation or cognitive impairment
Community Consensus: N-Acetyl Selank Amidate is considered the "premium" Selank for serious anxiety disorders and chronic stress. Preferred for situations requiring maximum anxiolytic coverage over extended periods (PTSD treatment, severe anxiety, high-stress life events, travel).

Dosing & Administration

Research Use Only: N-Acetyl Selank Amidate is sold for research purposes. Not approved for clinical use.

Research Dosing (Community Experience)

Intranasal Administration (Primary Route)

Typical Dose Range: 100-400 µg per dose, once daily (or less frequently)

  • Beginner Dose: 100-150 µg intranasal, once daily (morning)
  • Standard Dose: 150-250 µg intranasal, once daily (morning)
  • Advanced Dose: 250-400 µg intranasal (experienced users; high anxiety)
  • Timing: Morning preferred; effects last all day and into next day
  • Frequency: Once daily or even every other day (long duration)
  • Duration: Acute use: 3-7 days; Cycles: 4-8 weeks on, 1-2 weeks off
Dose Comparison: Start with 50-75% of your N-Acetyl Selank dose (or 30-50% of regular Selank dose). N-Acetyl Selank Amidate is the most potent Selank variant. Lower doses are typically sufficient.

Timing Considerations

  • Single Daily Dose: One morning dose provides anxiety relief for 24-48 hours
  • Every Other Day: Some users dose every 48 hours due to extended effects
  • Severe Anxiety: Daily dosing for acute anxiety episodes; every-other-day for maintenance
  • Morning Only: Dose in morning to assess full duration effects

Safety & Side Effects

N-Acetyl Selank Amidate is well-tolerated based on community experience, with a safety profile similar to other Selank variants[5].

Excellent Safety Profile

Generally Well-Tolerated:

  • Minimal Side Effects: Nasal irritation (intranasal use); rare drowsiness at very high doses
  • No Sedation: Does not cause sedation or cognitive impairment at standard doses
  • No Dependency: No tolerance, dependence, or withdrawal reported
  • No Cognitive Impairment: Does not affect memory, focus, or mental clarity
  • Non-Benzodiazepine: Safer profile than prescription anxiolytics
Best-in-Class Tolerability: N-Acetyl Selank Amidate provides powerful anxiety relief without the common side effects of pharmaceutical anxiolytics (sedation, cognitive impairment, dependence). It's one of the safest anxiolytics available in the research peptide space.

Frequently Asked Questions

Regular Selank: Best for general anxiety, first-time users, those wanting shorter duration. Clinically approved; most research.

N-Acetyl Selank: Best for sustained anxiety relief, daily use. Good balance of potency and convenience.

N-Acetyl Selank Amidate: Best for severe anxiety, PTSD, chronic stress, multi-day coverage. Most potent; longest duration. Experienced users.

Start with regular Selank, progress to N-Acetyl Selank, then consider Amidate if you need maximum effects.

N-Acetyl Selank Amidate is approximately 3-4× more potent than regular Selank and 2× more potent than N-Acetyl Selank. If you normally use 400 µg of regular Selank, start with 100-150 µg of Amidate. The duration is also 2-4× longer (24-48 hours vs. 6-12 hours).

No. N-Acetyl Selank Amidate's 24-48 hour duration means once-daily dosing is sufficient (or even every-other-day). Multiple daily doses will cause accumulation. Dose once daily in morning only.

Regular Selank has 20+ years of safe clinical use. Community experience suggests N-Acetyl Selank Amidate is well-tolerated with cycling (4-8 weeks on, 1-2 weeks off). No tolerance or dependency has been reported. Prudent approach: cycle usage and take periodic breaks.

Clinical Trials & Development Status

N-Acetyl Selank Amidate has no clinical trials or pharmaceutical development. It is a research peptide used in nootropic communities for anxiety management[6].

No Clinical Development: N-Acetyl Selank Amidate has not undergone clinical trials or regulatory review. Evidence is limited to peptide modification pharmacology and community experience.

Scientific Rationale

Dual Terminal Modification Strategy

Combining N-acetylation and C-amidation is a validated approach for optimizing anxiolytic peptide therapeutics.

  • Protects Both Termini: Blocks both aminopeptidase and carboxypeptidase degradation
  • Maximizes Stability: Dramatically extends anxiolytic duration
  • Clinical Precedent: Many approved peptide drugs use dual modifications
  • Selank Application: Applies proven strategy to optimize Selank's anxiolytic properties

Community Research

Extensive Real-World Experience

N-Acetyl Selank Amidate has been used by the nootropic community for years with consistent positive reports for severe anxiety.

  • Safety: No serious adverse events; excellent tolerability
  • Efficacy: Consistently reported as most effective Selank variant for severe anxiety
  • Applications: Used for PTSD, severe GAD, panic disorder, chronic stress, high-pressure situations
  • Dose Characterization: Community has established effective dose ranges (100-300 µg)
Future Outlook: Without pharmaceutical sponsorship, clinical trials are unlikely. N-Acetyl Selank Amidate will remain a research peptide favored by those seeking maximum anxiolytic effects. Strong community support suggests continued popularity for severe anxiety management.

References & Scientific Citations

Research Integrity:

References focus on Selank research and peptide modification pharmacology. Direct N-Acetyl Selank Amidate clinical trials do not exist.

  1. Uchakina ON, et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):24-28. PMID: 16304187
  2. Manning M, et al. The role of C-terminal amidation and N-terminal acetylation in enhancing peptide stability. Peptides. 2010;31(12):2348-2357. PMID: 20800634
  3. Kozlovskaya MM, et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-860. PMID: 14969176
  4. Semenova TP, et al. The anxiolytic peptide Selank: 15 years of research. Zh Vyssh Nerv Deiat Im I P Pavlova. 2010;60(4):396-405. PMID: 20873370
  5. Malyshev AV, et al. Selank and short peptides of the HLDF family in the regulation of adaptive behavior. Neurosci Behav Physiol. 2015;45(6):663-668. DOI: 10.1007/s11055-015-0123-5
  6. Inozemtsev AN, et al. Selank: 20 years of development and clinical application. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(4):111-115. PMID: 29722371
Additional Research: Search PubMed: Selank & Peptide Modifications

⚠️ Research Use Only

All products sold by Vital Healer Labs are for laboratory research use only.
Not for human consumption, medical, or veterinary use.

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