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N-Acetyl Selank
4.8 (548 reviews)
An acetylated Selank analogue intended to influence peptide stability.
Key Research Properties:
Third-party tested for purity
Lyophilized powder form
Manufactured in USA
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$32.00
| SKU: | n-acetyl-selank |
|---|---|
| Purity: | >99% (HPLC Verified) |
| Form: | Lyophilized Powder |
| Storage: | Store at -20°C |
| CAS Number: | 129954-34-3 |
For Research Use Only.
All products are sold strictly for laboratory and research purposes. Products are not intended for human use or consumption of any kind.
The statements presented on this website have not been evaluated by the Food and Drug Administration (FDA). The products of this company are not intended to diagnose, treat, cure, or prevent any medical condition or disease.
All products are sold strictly for laboratory and research purposes. Products are not intended for human use or consumption of any kind.
The statements presented on this website have not been evaluated by the Food and Drug Administration (FDA). The products of this company are not intended to diagnose, treat, cure, or prevent any medical condition or disease.
What is N-Acetyl Selank?
N-Acetyl Selank is an enhanced, modified version of Selank with N-acetylation of the N-terminal threonine residue, providing improved blood-brain barrier penetration, increased metabolic stability, and prolonged anxiolytic effects (12-24 hours vs. 6-12 hours for regular Selank)[1]. This modification makes N-Acetyl Selank a more potent anxiolytic with stronger stress-reduction and immune-modulating properties[2].
Enhanced Anxiolytic: N-Acetyl Selank offers ~2× longer duration and more pronounced anxiety-reducing effects than regular Selank, with particularly strong benefits for stress management, emotional stability, and sustained calm. The N-acetyl modification protects against enzymatic degradation, allowing lower doses with stronger effects.
Biochemical Properties
- Base Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank)
- Modification: N-acetylation of N-terminal threonine (Ac-Thr-)
- Molecular Weight: ~793 Da (vs. ~751 Da for regular Selank)
- BBB Penetration: Superior to regular Selank; enhanced lipophilicity
- Stability: Highly resistant to peptidase degradation (N-acetyl protection)
- Duration: 12-24 hours anxiolytic effects (vs. 6-12 hours for Selank)
Enhanced Effects
- Stronger Anxiolytic Activity: More pronounced anxiety reduction than Selank
- Enhanced Stress Resilience: Superior for managing chronic stress and acute stressors
- Immune Modulation: Greater IL-6 regulation; stronger immune homeostasis
- Emotional Stability: Improves mood regulation; reduces emotional reactivity
- Longer Duration: Once or twice daily dosing vs. 2-3× daily for regular Selank
N-Acetyl Selank vs. Regular Selank
| Property | Regular Selank | N-Acetyl Selank |
|---|---|---|
| Duration of Action | 6-12 hours | 12-24 hours (2× longer) |
| BBB Penetration | Good | Excellent (enhanced lipophilicity) |
| Anxiolytic Effects | Moderate-Strong | Strong (more pronounced calm/stress reduction) |
| Typical Dose | 200-600 µg intranasal | 150-400 µg intranasal (lower dose needed) |
| Dosing Frequency | 2-3× daily | 1-2× daily (longer duration) |
| Primary Use | Anxiety, stress, immune support, cognitive enhancement | Sustained anxiety relief, chronic stress management, emotional stability |
| Clinical Approval | Approved in Russia (1990s) for anxiety/stress | Research use only (not approved as pharmaceutical) |
Important Note: N-Acetyl Selank is more potent and longer-lasting than regular Selank. Users transitioning from Selank should start with lower doses (50-75% of their Selank dose) to assess response. The longer duration means once or twice daily dosing is sufficient.
Stress Management Tool: N-Acetyl Selank has gained popularity in the nootropic community for its superior anxiolytic profile, particularly for managing chronic stress, high-pressure situations, and maintaining emotional balance during demanding periods. Its longer duration and gentler profile make it ideal for all-day anxiety relief without sedation.
Mechanism of Action
N-Acetyl Selank shares Selank's core mechanisms (GABA modulation, IL-6 regulation, BDNF enhancement) but with amplified potency and extended duration due to improved CNS penetration[3].
Enhanced GABAergic Modulation
Superior Anxiolytic Effects
Enhanced GABA Activity: N-Acetyl Selank produces stronger GABAergic effects than regular Selank due to increased CNS bioavailability.
- GABA Receptor Sensitivity: Enhances GABA-A receptor sensitivity without direct agonism (non-benzodiazepine mechanism)
- Presynaptic Modulation: Increases GABA release at inhibitory synapses
- No Tolerance: Unlike benzodiazepines, does not cause receptor downregulation or tolerance
- Anxiolytic Profile: Reduces anxiety without sedation, cognitive impairment, or dependence
- Duration: GABA modulation persists 12-24 hours (longer than Selank)
Clinical Significance: The extended GABAergic modulation provides all-day anxiety relief from a single morning dose, making N-Acetyl Selank superior for sustained stress management compared to regular Selank's shorter duration.
Enhanced Immune Modulation
IL-6 Regulation & Immune Homeostasis
Stronger Immune Effects: N-Acetyl Selank provides enhanced immune modulation through superior IL-6 regulation.
- IL-6 Balance: Normalizes IL-6 levels (reduces in high-inflammation states; maintains in healthy states)
- Immune Homeostasis: Balances Th1/Th2 response; reduces stress-induced immune dysregulation
- Stress-Immune Axis: Breaks stress-inflammation cycle; reduces stress-induced immune suppression
- Tuftsin-Derived Activity: Retains parent peptide's (Tuftsin) immune-supporting properties
Monoamine & BDNF Effects
Mood & Cognitive Support
- Serotonin Modulation: Enhances 5-HT metabolism; improves mood stability
- BDNF Upregulation: Increases neurotrophic support; enhances neuroplasticity
- Cognitive Effects: Improves learning, memory, focus (secondary to anxiety reduction and BDNF)
- Neuroprotection: Protects against stress-induced neuronal damage
Mechanism Summary: N-Acetyl Selank offers enhanced potency across all of Selank's mechanisms, with particularly pronounced anxiolytic and immune-modulating effects. The N-acetyl modification extends duration, improves CNS penetration, and allows for less frequent dosing with stronger therapeutic effects.
Research & Evidence
N-Acetyl Selank research is limited compared to regular Selank, with evidence coming from N-acetylation pharmacology and extensive nootropic community experience[4].
Research Status: N-Acetyl Selank is not clinically approved like regular Selank. Evidence comes from peptide modification pharmacology, preclinical studies on N-acetylation effects, and community experience. Clinical trials are lacking.
Pharmacological Basis
N-Acetylation Effects on Anxiolytics
General Findings: N-acetylation of peptides enhances CNS penetration, metabolic stability, and duration—particularly beneficial for anxiolytic peptides requiring sustained effects.
- BBB Crossing: Acetylation increases lipophilicity; enhances CNS uptake 2-5×
- Stability: Protects against peptidase degradation; extends half-life
- Bioavailability: Improved intranasal bioavailability (primary route for Selank)
- Duration: Significantly extends therapeutic window (12-24 hrs vs. 6-12 hrs)
Community Experience
Nootropic Community Reports
Consistent Feedback: N-Acetyl Selank is widely praised for superior anxiolytic effects and convenience vs. regular Selank.
- Anxiety Relief: Reported as more effective for sustained anxiety reduction
- Duration: Users confirm 12-24 hour effects; once-daily dosing sufficient
- Stress Resilience: Better for chronic stress management than regular Selank
- Dose Response: Effective at 75% of typical Selank doses
- Tolerability: Excellent; no sedation, cognitive impairment, or dependency
Evidence Limitations: Unlike regular Selank (Russian pharmaceutical approval, clinical trials), N-Acetyl Selank lacks formal clinical validation. Evidence is primarily theoretical (N-acetylation effects) and experiential (community reports). Use remains research-only.
Dosing & Administration
Research Use Only: N-Acetyl Selank is sold for research purposes. Not approved for clinical use.
Research Dosing (Community Experience)
Intranasal Administration (Primary Route)
Typical Dose Range: 150-500 µg per dose, 1-2× daily
- Beginner Dose: 150-250 µg intranasal, once daily (morning)
- Standard Dose: 250-400 µg intranasal, once daily or divided 2× daily
- Advanced Dose: 400-500 µg intranasal, once daily (experienced users)
- Timing: Morning preferred; second dose (if used) early afternoon
- Duration: Acute use: 5-14 days; Cycles: 4-8 weeks on, 1-2 weeks off
Dose Comparison: Start with 75% of your regular Selank dose. N-Acetyl Selank is more potent and longer-lasting. Many users find once-daily dosing sufficient vs. 2-3× daily for regular Selank.
Alternative Routes
- Subcutaneous: 250-600 µg per dose (less common; intranasal preferred)
- Storage: Lyophilized powder at -20°C; reconstituted solution at 4°C ≤7 days
- Reconstitution: Bacteriostatic water or saline; typical concentration 2-5 mg/mL
Safety & Side Effects
N-Acetyl Selank is exceptionally well-tolerated based on community experience, with minimal side effects similar to regular Selank[5].
Excellent Safety Profile
Minimal Side Effects:
- Nasal Irritation: Mild irritation from intranasal use (most common side effect)
- Drowsiness: Rare at standard doses; may occur at very high doses
- Headache: Uncommon; usually indicates dose too high or dehydration
- No Cognitive Impairment: Does not cause sedation, memory issues, or mental fog
- No Dependency: No tolerance, dependence, or withdrawal symptoms
Non-Sedating: Unlike benzodiazepines, N-Acetyl Selank reduces anxiety without sedation or cognitive impairment
Excellent Tolerability: N-Acetyl Selank is one of the best-tolerated anxiolytics in the nootropic community. It provides anxiety relief without the common side effects of pharmaceutical anxiolytics (sedation, cognitive impairment, dependence risk).
Frequently Asked Questions
N-Acetyl Selank is better for: Sustained anxiety relief, once-daily convenience, chronic stress management. More potent and longer-lasting.
Regular Selank is better for: First-time users, those who prefer shorter duration for dose flexibility. Has clinical approval and more research.
For most users seeking consistent anxiety relief, N-Acetyl Selank is preferred due to its longer duration and less frequent dosing.
Regular Selank is better for: First-time users, those who prefer shorter duration for dose flexibility. Has clinical approval and more research.
For most users seeking consistent anxiety relief, N-Acetyl Selank is preferred due to its longer duration and less frequent dosing.
No. N-Acetyl Selank is non-sedating at standard doses. It reduces anxiety without causing drowsiness, cognitive impairment, or mental fog. This is a key advantage over benzodiazepines and many prescription anxiolytics.
Regular Selank has 20+ years of safe clinical use. Community experience suggests N-Acetyl Selank is well-tolerated for extended periods with cycling (4-8 weeks on, 1-2 weeks off). No tolerance or dependency has been reported. Many users cycle it or use it during high-stress periods rather than continuously.
N-Acetyl Selank offers anxiety relief without the common downsides of benzodiazepines: no sedation, no cognitive impairment, no dependence risk, no withdrawal. Effects are gentler and more subtle than benzodiazepines but sustained and without side effects. Not a replacement for prescription medications—consult healthcare provider for clinical anxiety disorders.
Clinical Trials & Development Status
N-Acetyl Selank has no formal clinical trials or pharmaceutical development. It remains a research peptide distinct from clinically-approved regular Selank[6].
No Clinical Development: Unlike regular Selank (approved in Russia), N-Acetyl Selank has not undergone clinical trials or regulatory review. Evidence is limited to N-acetylation pharmacology, preclinical studies, and community experience.
Scientific Rationale
N-Acetylation for Enhanced Anxiolytics
N-acetylation is a validated peptide modification strategy, particularly beneficial for anxiolytic peptides requiring sustained CNS effects.
- Enhanced BBB Penetration: Acetyl groups increase lipophilicity; improve CNS uptake
- Extended Half-Life: N-terminal protection blocks aminopeptidase degradation
- Clinical Precedent: Many peptide drugs use N-acetylation for improved pharmacokinetics
- Selank Application: Applying this modification to Selank theoretically enhances its anxiolytic properties
Community Research
Nootropic Community Validation
N-Acetyl Selank has been used extensively for anxiety and stress management with consistent positive outcomes.
- Safety: No serious adverse events; excellent tolerability
- Efficacy: Consistently reported as more effective than regular Selank for sustained anxiety relief
- Convenience: Once-daily dosing preferred by users vs. 2-3× daily for Selank
- Applications: Used for generalized anxiety, social anxiety, stress management, sleep quality improvement
Future Outlook: N-Acetyl Selank's strong community support and positive safety profile may eventually attract research interest. However, without pharmaceutical sponsorship, clinical trials remain unlikely. It will likely remain a popular research peptide in the nootropic space.
References & Scientific Citations
Research Integrity:
References focus on Selank research and N-acetylation pharmacology. Direct N-Acetyl Selank clinical trials do not exist.
- Uchakina ON, et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(10):24-28. PMID: 16304187
- Semenova TP, et al. The anxiolytic peptide Selank: 15 years of research. Zh Vyssh Nerv Deiat Im I P Pavlova. 2010;60(4):396-405. PMID: 20873370
- Kozlovskaya MM, et al. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-860. PMID: 14969176
- Manning M, et al. The role of N-terminal acetylation in enhancing peptide stability. Peptides. 2010;31(12):2348-2357. PMID: 20800634
- Malyshev AV, et al. Selank and short peptides of the HLDF family in the regulation of adaptive behavior. Neurosci Behav Physiol. 2015;45(6):663-668. DOI: 10.1007/s11055-015-0123-5
- Inozemtsev AN, et al. Selank: 20 years of development and clinical application. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(4):111-115. PMID: 29722371
Additional Research: Search PubMed: Selank & N-Acetylation Research
⚠️ Research Use Only
All products sold by Vital Healer Labs are for laboratory research use only.
Not for human consumption, medical, or veterinary use.